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17α-Methyltestosterone

Cat. No. M6106
17α-Methyltestosterone Structure
Synonym:

Methyltestosterone; 17-Methyltestosterone

Size Price Availability Quantity
100mg USD 60  USD60 In stock
500mg USD 105  USD105 In stock
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Quality Control & Documentation
Biological Activity

17α-meT is a Class III AAS with an alkylation at C-17 and with restricted potential of metabolizing substrates for aromatization. In fact, 17α-meT cannot be aromatize to 17β-estradiol, the most potent form of mammalian estrogenic steroids, and the main product of aromatase. A single injection of 17α-meT immediately before the footshock produced significant impairment of inhibitory avoidance learning in males but not females. Our results show that exposure to a single pharmacological dose of 17α-meT during periadolescence exerts sex-specific cognitive effects without affecting anxiety.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Gonadally-intact male and female Sprague Dawley rats
Formulation 0.9% saline containing 30% cyclodextrin
Dosages 7.5 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 302.45
Formula C20H30O2
CAS Number 58-18-4
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] El-Desoky el-SI, et al. Steroids. Synthesis and chemical reactions of the steroidal hormone 17α-methyltestosterone.

[2] Ramos-Pratts K, et al. Behav Processes. Sex-specific effect of the anabolic steroid, 17α-methyltestosterone, on inhibitory avoidance learning in periadolescent rats.

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Keywords: 17α-Methyltestosterone, Methyltestosterone; 17-Methyltestosterone supplier, Androgen Receptor, inhibitors, activators


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