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Clascoterone (Cortexolone 17α-propionate, CB-03-01) is a new selective androgen receptor (AR) antagonist.
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Source | J Microbiol Biotechnol (2016). Figure 4. 17 alpha-propionate |
| Method | Western Blot | |
| Cell Lines | bacteria | |
| Concentrations | 140 mg/l | |
| Incubation Time | 6 h | |
| Results | As shown in Fig. 4, propionate-oxidizing bacteria relevant band B3 was enhanced with the pH decrease rom 7.1 to 6.0, indicating that this propionate degrader (band B3) is slightly acid tolerant. |
| Cell Experiment | |
|---|---|
| Cell lines | PBMC |
| Preparation method | Because of the extent of these experiments, the drugs were divided into two groups: dexamethasone, budesonide, beclomethasone dipropionate and fluticasone (first group); and dexamethasone, CsA, FK506 (tacrolimus) and mycophenolate (second group). |
| Concentrations | 10^-2 mol/L |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Female Golden hamsters |
| Formulation | 0.05 mL of acetone containing 4 μg of testosterone propionate (TP) |
| Dosages | 100−200−400 μg/animal |
| Administration | s.c. |
| Molecular Weight | 402.52 |
| Formula | C24H34O5 |
| CAS Number | 19608-29-8 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Androgen Receptor Products |
|---|
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Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications such as prostate cancer. |
| SC912
SC912 is a potent and selective AR-V7 inhibitor with IC50 of 0.36 μM. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis. |
| A4B17
A4B17 is an androgen receptor N-terminal inhibitor, which can be used for the research of androgen-responsive prostate cancer. |
| AZ'3137
AZ‘3137 is an orally active PROTAC-type androgen receptor (AR) degrader, with a DC50 value of 22 nM. |
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