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13α (21)-Epoxyeurycomanone

Cat. No. M18244
13α (21)-Epoxyeurycomanone Structure
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Biological Activity

13α（21）-Epoxyeurycomanone

Chemical Information
Molecular Weight 424.4
Formula C20H24O10
CAS Number 138809-10-6
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Young Min Han, et al. J Sep Sci. Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry

[2] Omar Saeed Ali Al-Salahi, et al. Microvasc Res. Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates endothelial cell function

[3] Bin-Seng Low, et al. Nat Prod Commun. Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity

[4] Chin-Hoe Teh, et al. J Chromatogr A. Developing a validated liquid chromatography-mass spectrometric method for the simultaneous analysis of five bioactive quassinoid markers for the standardization of manufactured batches of Eurycoma longifolia Jack extract as antimalarial medicaments

[5] Walther H Wernsdorfer, et al. Wien Klin Wochenschr. Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro

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