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3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin

Cat. No. M40153
3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin Structure
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Biological Activity

3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin is a flavonoid that can be isolated from Quercus ilex.

Chemical Information
Molecular Weight 824.74
Formula C43H36O17
CAS Number 137018-33-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Takatoshi Nakagawa et al. Carbohydr Res. Preparation, characterization, and biological evaluation of 6(I),6(IV)-di-O-[α-l-fucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose and 6-O-[α-l-fucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose

[2] M A Shalaby et al. Carbohydr Res. Synthesis of 3,4-di-O-acetyl-2,5-anhydro-1,6-dideoxy-1,6-diiodo-D-mannitol. Comparison of NMR spectral results for the solid state and solution with those of the X-ray structural determination

[3] M A Shalaby et al. Acta Crystallogr C. 3,4-di-O-acetyl-2,5-anhydro-1,6-di-O-(p-tolylsulfonyl)-D-mannitol

[4] M A Shaban et al. Carbohydr Res. The synthesis of 2-acetamido-2-deoxy-6-O-beta-D-mannopyranosyl-D-glucose

[5] K L Matta et al. Carbohydr Res. Synthesis of p-nitrophenyl 2-acetamido-2-deoxy-O-beta-D-galactopyranosyl-beta-D-glucopyranosides

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Keywords: 3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin supplier, Others, inhibitors, activators


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