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12-Hydroxyjasmonic acid

Cat. No. M28353
12-Hydroxyjasmonic acid Structure
Synonym:

(-)-12-Hydroxyjasmonic acid

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Biological Activity

12-Hydroxyjasmonic acidis is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman.

Chemical Information
Molecular Weight 226.27
Formula C12H18O4
CAS Number 140631-27-2
Form Oil
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gangqiang Yang, et al. Sci Rep. 12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation

[2] Emilie Widemann, et al. J Biol Chem. The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves

[3] Yoshiya Seto, et al. Biosci Biotechnol Biochem. Tobacco salicylic acid glucosyltransferase is active toward tuberonic acid (12-hydroxyjasmonic acid) and is induced by mechanical wounding stress

[4] Yoko Nakamura, et al. Plant Physiol. 12-hydroxyjasmonic acid glucoside is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman

[5] Catherine Koukoulitsa, et al. Bioorg Med Chem. Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum

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Keywords: 12-Hydroxyjasmonic acid, (-)-12-Hydroxyjasmonic acid supplier, inhibitors, activators


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