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11C,14C-Eicosadienoic Acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues. Eicosadienoic acid inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 308.5 |
| Formula | C20H36O2 |
| CAS Number | 2091-39-6 |
| Purity | liquid, >98% |
| Solubility | |
| Storage | -20°C, sealed |
Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages
Yung-Sheng Huang, et al. Mol Cell Biochem. 2011 Dec;358(1-2):85-94. PMID: 21688154.
Essential fatty acids are antagonists of the leukotriene B4 receptor
K A Yagaloff, et al. Prostaglandins Leukot Essent Fatty Acids. 1995 May;52(5):293-7. PMID: 7630916.
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| Myristic acid
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| N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine)
N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite, it is the important constituent of brain heteropolysaccharides (glycoproteins). |
| Atranorin
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