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11C,14C-Eicosadienoic Acid

Cat. No. M10216
11C,14C-Eicosadienoic Acid Structure
Synonym:

cis-11,14-Eicosadienoic acid

Size Price Availability Quantity
25mg USD 249.3  USD277 In stock
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Quality Control
  • Current batch:
  • Purity liquid, >98%
  • COA
  • MSDS
Biological Activity

11C,14C-Eicosadienoic Acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues. Eicosadienoic acid inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 308.5
Formula C20H36O2
CAS Number 2091-39-6
Purity liquid, >98%
Solubility
Storage -20°C, sealed
References

Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages
Yung-Sheng Huang, et al. Mol Cell Biochem. 2011 Dec;358(1-2):85-94. PMID: 21688154.

Essential fatty acids are antagonists of the leukotriene B4 receptor
K A Yagaloff, et al. Prostaglandins Leukot Essent Fatty Acids. 1995 May;52(5):293-7. PMID: 7630916.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 11C,14C-Eicosadienoic Acid, cis-11,14-Eicosadienoic acid supplier, Endogenous Metabolite, inhibitors

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