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1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one

Cat. No. M38632
1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one Structure
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Biological Activity

1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one is an acridone alkaloid compound isolated from the fruits of Z. leprieurii and Z. zanthoxyloides. 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has antibacterial activity.

Chemical Information
Molecular Weight 271.27
Formula C15H13NO4
CAS Number 1189362-86-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alessia Scatena et al. ACS Chem Neurosci. 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects

[2] Sabrina Taliani et al. J Med Chem. 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists

[3] Giampaolo Primofiore et al. Arch Pharm (Weinheim). Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor

[4] R K Thalji et al. Acta Crystallogr C. A diiodo-substituted 9-anthracenone

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Keywords: 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one supplier, Antibiotic, inhibitors, activators

 
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