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1-Acetyl-β-carboline

Cat. No. M30207
1-Acetyl-β-carboline Structure
Synonym:

1-(9H-pyrido[3,4-b]indol-1-yl)ethanone

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Biological Activity

1-Acetyl-β-carboline is metabolite of Nonomuraea endophytica.

Chemical Information
Molecular Weight 210.23
Formula C13H10N2O
CAS Number 50892-83-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guy Kleks, et al. J Nat Prod. Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

[2] Khaled A Shaaban, et al. J Nat Prod. Karamomycins A-C: 2-Naphthalen-2-yl-thiazoles from Nonomuraea endophytica

[3] Paul Owusu Donkor, et al. J Ethnopharmacol. Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics

[4] Hee Jae Shin, et al. J Microbiol Biotechnol. The synergistic antibacterial activity of 1-acetyl-beta-carboline and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA)

[5] Ina Nemet, et al. Bioorg Med Chem. The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-beta-carbolines

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Keywords: 1-Acetyl-β-carboline, 1-(9H-pyrido[3,4-b]indol-1-yl)ethanone supplier, Others, inhibitors, activators

 
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