Propylene glycol (1,2-propanediol) is a synthetic liquid substance that can be used as a solvent and excipient for oral and topical compounds. Propylene glycol has good solubility and less toxicity and irritation, and is widely used as solvents, extraction solvents and preservatives for injections and non-injectable pharmaceutical preparations. It is better than glycerol solvent and can dissolve many substances such as corticosteroids, chloramphenicol, sulfonamides, barbiturate, reserpine, quinidine, corticosterone acetate, tetrahydropalmatine sulfate, mechlorethamine hydrochloride, vitamin A, vitamin D, many volatile oils, most of the alkaloids and many local anesthetics.
Propylene glycol is commonly used as a plasticizer for the aqueous film coating materials. Its mixture with equal amounts of water can delay the hydrolysis of certain drugs, and increase the stability of the preparation product. It is used as an antimicrobial preservative in 15% to 30% propylene glycol solution and semi-solid formulation, as humectants in about 15% propylene glycol topical formulation, and as solvent and co-solvent in 10% to 30% propylene glycol aerosol solvent, 10% to 25 % propylene glycol oral solution, 10% to 60% injectable formulation and 5% to 80% topical formulation.
Propylene glycol is very stable at room temperature, but is oxidized when left open at high temperatures (above 280 °C); has a chemical stability after mixing with 95% ethanol or water; can be sterilized by autoclaving or sterile filtration. Propylene glycol has hygroscopicity, and should be positioned at cool and dry place and stored in dark airtight container.
| Molecular Weight | 76.09 |
| Formula | C3H8O2 |
| CAS Number | 57-55-6 |
| Solubility (25°C) | Miscible with Water |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Solvents & Excipients Products |
|---|
| Dimethyl sulfoxide
Dimethyl sulfoxide (DMSO) is a commonly used organic solvent with high solvency capacity, soluble in most organic substances such as water, ethanol, propanol, ether, benzene and chloroform, and can be used for the dissolution of compounds and other products. |
| ATX-002
ATX-002 is an ionizable cationic lipid for RNA drug delivery with theoretical pKa (c-pKa) and measured pKa values of 8.68 and 6.03, respectively. |
| 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phospholipid that can be used in studies related to drug delivery. |
| PEG1500
PEG1500 is a polymer produced by the condensation reaction of ethylene oxide and water, generally white waxy solid in appearance, often used as a pharmaceutical excipient. |
| PLGA lactide:glycolide (50:50) (MW 90000)
PLGA lactide:glycolide (50:50) (MW 90000) Poly(D,L-propylidene-CO-ethylidene glycolide) is a synthetic amino acid that can be used for macromolecular delivery. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
