| Cat.No. | Name | Information |
|---|---|---|
| M55019 | ORIC-944 | ORIC-944 is a selective, orally active, allosteric inhibitor targeting the EED subunit of polycomb repressive complex 2 (PRC2). ORIC-944 is synergistic with androgen receptor pathway inhibitors (ARPIs) for the study of metastatic prostate cancer. |
| M11244 | A-395 | A-395 is A Polycomb inhibitory complex 2 (Polycomb repressive complex 2; PRC2), a protein-protein interaction antagonist, inhibits the trimer PRC2 complex (ezh2-EED -SUZ12) with an IC50 value of 18 nM. |
| M6163 | MAK683 | MAK-683 is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2). |
| M5243 | EED226 | EED226 is an effective, selective and orally active Polycomb reactive complex 2 (PRC2) inhibitor. When h3k27me0 peptide is used as substrate, ic50=23.4 nm; With mononucleosome as substrate, ic50=53.5 nm. It is a first in class, effective, orally bioavailable inhibitor of embryonic ectodermal development (EED) with strong anticancer effect. |
| M11356 | EEDi-5285 | Eedi-5285 is a highly effective and orally active inhibitor of embryonic ectodermal development (EED). The IC50 value of BINDING EED protein is 0.2 nM, and it has anticancer activity. |
| M11355 | EEDi-5273 | Eedi-5273 is a potent and orally effective EED inhibitor (IC50 = 0.2 nM) that can achieve complete and sustained tumor regression. |
| M11015 | FTX-6058 | FTX-6058 is a potent, orally active embryonic ectodermal development (EED) inhibitor. FTX-6058 can induce HbF protein expression in both cell and murine models. FTX-6058 can be used in the study of specific hemoglobinopathies, including sickle cell disease and β-thalassemia. |
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