| Cat.No. | Name | Information |
|---|---|---|
| M2050 | GSK2636771 | GSK2636771 is a potent, orally available and specific PI3K p110β (PI3K beta, PI3Kβ) inhibitor. |
| M1925 | LY294002 | LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. |
| M2296 | 3-Methyladenine (3-MA) | 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively. |
| M1715 | GDC-0941 (Pictilisib) | GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM. |
| M1984 | PF-04691502 | PF-04691502 is a potent and selective, ATP-competitive PI3K/mTOR inhibitor with IC50 of 7.5 nM and 3.8 nM of AKT T308 and AKT S473, respectively. |
| M2053 | Wortmannin (KY 12420) | Wortmannin (KY 12420) is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM. |
| M1680 | BKM120 (Buparlisib) | BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor. |
| M1819 | A66 | A66 is a potent and specific inhibitor of PI3K p110α with IC50 values of 32, 30 and 43 nM for p110α, p110α/E545K and p110α/H1047R. |
| M1671 | BEZ235 | BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively. |
| M1773 | PI-103 | PI-103 is a potent, ATP-competitive PI3K,cell-permeable,inhibitor.The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γrespectively. |
| M49898 | SNV4818 | SNV4818 is a potential best-in-class (best-in-class) mutation-selective PI3K-α inhibitor with excellent selectivity for the H1047X mutant and moderate selectivity for the related E545/542X mutant. |
| M43403 | EDI048 | EDI048 is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis. |
| M43402 | PI3Kδ-IN-13 | PI3Kδ-IN-13 is a PI3Kδ inhibitor (IC50=2.6 nM). |
| M43401 | PI3Kα-IN-13 | PI3Kα-IN-13 is a PI3Kα inhibitor (IC50: 2.5 nM). |
| M43400 | FD2056 | FD2056 is a potent and orally active PI3K inhibitor. |
| M43399 | Acetyl-Exenatide | Acetyl-Exenatideyes is an acetylated derivative of Exenatide. |
| M43398 | PI3Kδ-IN-14 | PI3Kδ-IN-14 is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). |
| M43397 | Leniolisib phosphate | Leniolisib (CDZ173) phosphate is a first-in-class, potent and selective PI3Kδ inhibitor with an IC50 value of 11 nM.Leniolisib is more selective for PI3K-δ than PI3K-α (28-fold), PI3K-β (43-fold) and PI3K-γ (257-fold). -γ (257-fold). In a cellular assay, Leniolisib decreased pAKT pathway activity and inhibited the proliferation and activation of B and T cell subsets. |
| M43396 | UCL-TRO-1938 | UCL-TRO-1938 is a potent allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. |
| M43395 | CXJ-2 | CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). |
| M43394 | Nemiralisib hydrochloride | Nemiralisib hydrochloride (GSK2269557) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9. |
| M43393 | PI3Kδ-IN-12 | PI3Kδ-IN-12 is a PI3Kδ inhibitor (pIC50 = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. |
| M43392 | PI3K-IN-41 | PI3K-IN-41 is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. |
| M43391 | PI3K-IN-47 | PI3K-IN-47 is a bivalent PI3K inhibitor (IC50: 0.44 nM for PI3Kα, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, PI3Kδ). |
| M43390 | IHMT-PI3K-455 | IHMT-PI3K-455 is a potent, selective, orally active PI3Kγ/δ dual inhibitor with IC50s of 7.1 nM and 0.57 nM for PI3Kγ and PI3Kδ, respectively. |
| M43389 | FD274 | FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. |
| M43388 | PI3Kγ inhibitor 7 | PI3Kγ inhibitor 7 is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. |
| M43387 | SN32976 | SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC50s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. |
| M39840 | Hirsutenone | Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. |
| M39839 | Boc-L-cyclobutylglycine | Boc-L-cyclobutylglycine is a glycine derivative that can be used for PI3K inhibitor synthesis. |
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