| Cat.No. | Name | Information |
|---|---|---|
| M54532 | IDH1 Inhibitor 2 | IDH1 Inhibitor 2 is a potent wild-type IDH1 inhibitor that acts through covalent modification of His315 and has an IC50 value of 110 nM. |
| M54531 | (S,R)-GSK321 | (S,R)-GSK321 is a potent and selective inhibitor of mutant IDH1, inhibiting R132G, R132C, R132H, and WT IDH1 with IC50 values of 2.9, 3.8, 4.6, and 46 nM, respectively, with a 100-fold higher selectivity than IDH2. (S,R)-GSK321 induces a reduction in intracellular 2-HG, failure of myeloid differentiation blockade, and induction of granulocyte differentiation at the level of leukemoblasts and more immature stem cells. (S,R)-GSK321 can be used in studies related to acute myeloid leukemia (AML) and other cancers. |
| M54530 | (1R)-IDH889 | (1R)-IDH889 is the inactive isomer of IDH889, which serves as a control compound in experiments.IDH889 is an orally active, brain-permeable, variant- and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1).IDH889 is highly selective for the IDH1 R132 mutant, and acts efficiently on IDH1R132H, IDH1R132C and IDH1wt with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM, respectively.In addition, IDH889 has a potent and potent effect on IDH1R132C and IDH1wt, IDH889 is highly selective for the IDH1 R132 mutant, with IC50 values of 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt, respectively, and has a high potency to inhibit the level of intracellular 2-HG, with an IC50 value of 0.014 μM. |
| M42452 | IHMT-IDH1-053 | IHMT-IDH1-053 is a highly selectivity and irreversible IDH1-mutant inhibitor with an IC50 of 4.7 nM for IDH1 R132H. |
| M28911 | GSK321 | GSK321 is a potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) enzymes. GSK321 has high inhibitory and selectivity for mutant IDH1 enzymes. GSK321 can be used for the research of acute myeloid leukemia. |
| M14455 | Mutant IDH1-IN-2 | Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. |
| M14452 | (R,S)-Ivosidenib | (R,S)-Ivosidenib ((R,S)-AG-120) is the less active enantiomer of Ivosidenib (AG-120). |
| M8535 | Bis-Imidazole phenol IDH1 inhibitor | bis-Imidazole phenol is a potent and cell permeable inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant R132H that inhibits D-2-hydroxyglutaric acid (2HG) production in cells. |
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