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IHMT-IDH1-053

Cat. No. M42452

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IHMT-IDH1-053 Structure

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Quality Control & Documentation
Biological Activity

IHMT-IDH1-053 is a highly selectivity and irreversible IDH1-mutant inhibitor with an IC50 of 4.7 nM for IDH1 R132H.

Chemical Information
Molecular Weight 532.63
Formula C25H33FN6O4S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qianmao Liang et al. Eur J Med Chem. Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor

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(S,S)-GSK321

(S,S)-GSK321 is the (S,S)-enantiomer of GSK321.GSK321 is a potent inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme.

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IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-permeable, selective mutant IDH1 inhibitor that inhibits IDH1R132H, IDH1R132C, and IDH1WT with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM, respectively. possesses antitumor activity.

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  Catalog
Abmole Inhibitor Catalog




Keywords: IHMT-IDH1-053 supplier, Isocitrate Dehydrogenase (IDH), inhibitors, activators

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