Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M27658 | GSK-626616 | GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia. |
| M21230 | GNF2133 | GNF2133 is a potent, selective, orally active DYRK1A inhibitor with IC50s of 0.0062 and >50 µM for DYRK1A and GSK3β, respectively. GNF2133 has potential for the study of type 1 diabetes. |
| M14889 | GNF4877 | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). |
| M9537 | Protein kinase inhibitors 1 | Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. |
| M6787 | Harmine | Harmine is a potent and selective DYRK1A inhibitor. |
| M4741 | Harmine-hydrochloride | Harmine Hydrochloride (Telepathine Hydrochloride) is a DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine Hydrochloride has a high affinity for 5-HT2A serotonin receptor, with a Ki value of 397 nM. |
| M2765 | ID-8 | Id-8 is a DYRK inhibitor that maintains the self-renewal of embryonic stem cells in long-term culture. |
| M50425 | Woodtide | Woodtide is a substrate for the DYRK (DYRK) family of kinases whose sequence is based on that around the DYRK phosphorylation site in FKHR. |
| M39844 | Aristolactam A IIIa | Aristolactam A IIIa (Sch 546909) is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells. |
| M28808 | Dyrk1A-IN-5 | Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research. |
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