Discoidin Domain Receptor Discoidin domain receptors (DDRs)

Inhibitor

Cat.No.	Name	Information
M21468	DDR1-IN-4	DDR1-IN-4 is an effective and selective inhibitor of disk peptide domain receptor 1 (DDR1) autophosphorylation, with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively.
M43492	DDR1/2 inhibitor-2	DDR1/2 inhibitor-2 is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM.
M29014	WRG-28	WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice.
M28770	DDR Inhibitor	DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.
M28467	BAY-826	BAY-826 is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively.