Inhibitor
Cat.No. | Name | Information |
---|---|---|
M21468 | DDR1-IN-4 | DDR1-IN-4 is an effective and selective inhibitor of disk peptide domain receptor 1 (DDR1) autophosphorylation, with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively. |
M57195 | DDR1-IN-1 dihydrochloride | DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM). |
M43492 | DDR1/2 inhibitor-2 | DDR1/2 inhibitor-2 is a DDR1/DDR2 inhibitor, with IC50 values less than 100 nM. |
M29014 | WRG-28 | WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice. |
M28770 | DDR Inhibitor | DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM. |
M28467 | BAY-826 | BAY-826 is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively. |
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