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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9769 | BP-1-102 | BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor with IC50 of 6.8 μM. |
| M9706 | Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M9077 | STAT5-IN-1 | STAT5-IN-1 is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain, with an IC50 of 47 μM for STAT5β isoform. |
| M8874 | C188-9 | C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling. |
| M7539 | AS1517499 | AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM. |
| M5264 | SH5-07 | SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models. |
| M5018 | Corylifol A | Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM). |
| M4622 | Garcinone D | Garcinone D is a natural xanthone from mangosteen, which increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in concentration- and time- dependent manners. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3970 | Scutellarin | Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a Chinese herb Erigeron breviscapus (Vant.) Hand.-Mazz. |
| M3928 | Scoparone | Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. |
| M3664 | SH-4-54 | SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. |
| M3648 | HO-3867 | HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. |
| M3032 | Stattic | Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. |
| M2883 | Nifuroxazide | Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| M2055 | Niclosamide | Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM. |
| M2028 | Fludarabine | Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor. |
| M1782 | NSC 74859 | NSC 74859 (S3I-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling. |
| M1293 | Artesunate | Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. |
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