|M9077||MDK-6314||MDK-6314 (STAT5-IN-1) is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain, with an IC50 of 47 μM for STAT5β isoform.|
|M8874||C188-9||C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.|
|M7539||AS1517499||AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.|
|M5264||SH5-07||SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.|
|M5018||Corylifol A||Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).|
|M3982||Cryptotanshinone||Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.|
|M3928||Scoparone||Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver.|
|M3664||SH-4-54||SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.|
|M3648||HO-3867||HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.|
|M3219||S3I-M2001||S3I-M2001 is a selective disruptor of STAT3:STAT3 dimerization and inhibitor of STAT3 activation with IC50 of 79 μM.|
|M3032||Stattic||Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.|
|M2055||Niclosamide||Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM.|
|M2028||Fludarabine||Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor.|
|M1782||NSC 74859||NSC 74859 (S3I-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling.|
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