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Abmole Inhibitor Catalog 2017

STAT Signal transduction and activator of transcription


Cat.No.  Name Information
M5264 SH5-07 SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
M5018 Corylifol A Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).
M3982 Cryptotanshinone Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.
M3928 Scoparone Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver.
M3664 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
M3648 HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
M3219 S3I-M2001 S3I-M2001 is a selective disruptor of STAT3:STAT3 dimerization and inhibitor of STAT3 activation with IC50 of 79 μM.
M3032 Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
M2055 Niclosamide Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM.
M2028 Fludarabine Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor.
M1782 NSC 74859 NSC 74859 (S3I-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling.

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