Catalog

STAT Signal transduction and activator of transcription

Inhibitors

Cat.No.	Name	Information
M10077	Colivelin	Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3.
M9769	BP-1-102	BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor with IC50 of 6.8 μM.
M9706	Colivelin TFA	Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3.
M9077	STAT5-IN-1	STAT5-IN-1 is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain, with an IC50 of 47 μM for STAT5β isoform.
M8874	C188-9	C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.
M7747	Diosgenin	Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells.
M7539	AS1517499	AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.
M5264	SH5-07	SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
M5018	Corylifol A	Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).
M4622	Garcinone D	Garcinone D is a natural xanthone from mangosteen, which increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in concentration- and time- dependent manners.
M3982	Cryptotanshinone	Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.
M3970	Scutellarin	Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a Chinese herb Erigeron breviscapus (Vant.) Hand.-Mazz.
M3928	Scoparone	Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver.
M3664	SH-4-54	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
M3648	HO-3867	HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
M3032	Stattic	Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
M2883	Nifuroxazide	Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
M2055	Niclosamide	Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM.
M2028	Fludarabine (NSC 118218)	Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor.
M1782	NSC 74859	NSC 74859 (S3I-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling.
M1293	Artesunate	Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.

Signaling Pathways

Product Type

STAT Signal transduction and activator of transcription

Get to Know Us

Customer Support

Resources

Contact Us