Catalog

STAT Signal transduction and activator of transcription

Inhibitors

Cat.No.	Name	Information
M5264	SH5-07	SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
M5018	Corylifol A	Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).
M3982	Cryptotanshinone	Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.
M3928	Scoparone	Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver.
M3664	SH-4-54	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
M3648	HO-3867	HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
M3219	S3I-M2001	S3I-M2001 is a selective disruptor of STAT3:STAT3 dimerization and inhibitor of STAT3 activation with IC50 of 79 μM.
M3032	Stattic	Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
M2055	Niclosamide	Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM.
M2028	Fludarabine	Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor.
M1782	NSC 74859	NSC 74859 (S3I-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling.