| Cat.No. | Name | Information |
|---|---|---|
| M3648 | HO-3867 | HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3970 | Scutellarin | Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. |
| M2883 | Nifuroxazide | Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| M2028 | Fludarabine (NSC 118218) | Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor. |
| M3032 | Stattic | Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
| M7747 | Diosgenin | Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. |
| M4433 | Alantolactone | Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone (helenin, helenine, Eupatal) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. |
| M9706 | Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M10077 | Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M52823 | STAT3-IN-21, cell-permeable, negative control | STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection. |
| M52822 | STAT3-IN-24, cell-permeable | STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor. |
| M52821 | 5-FAM-GpYLPQTV-NH2 | 5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. |
| M52820 | Ac-GpYLPQTV-NH2 | Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. |
| M49690 | XZH-5 | XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability. |
| M49689 | STAT6-IN-1 | STAT6-IN-1 is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). |
| M49688 | STAT3-SH2 domain inhibitor 1 | STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. |
| M49687 | STAT3-IN-8 | STAT3-IN-8 is a potent STAT3 inhibitor. |
| M49686 | STAT3-IN-7 | STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. |
| M49685 | STAT3-IN-23 | STAT3-IN-23 (PY*LKTK) is a potent STAT3 inhibitor. |
| M49684 | STAT3-IN-17 | STAT3-IN-17 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. |
| M49683 | STAT3-IN-15 | STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). |
| M49682 | STAT3-IN-14 | STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. |
| M49681 | STAT3-IN-13 | STAT3-IN-13 is a potent STAT3 inhibitor. |
| M49680 | STAT3-IN-12 | STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. |
| M49679 | STAT3-IN-11 | STAT3-IN-11 is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. |
| M49678 | STAT3-IN-10 | STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. |
| M49677 | STAT3 degrader-1 | STAT3 degrader-1 is a potent STAT3 degrader. |
| M49676 | S-Propargylcysteine | S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. |
| M49675 | Prohibitin ligand 1 | Prohibitin ligand 1 , a cardioprotectant prohibitin ligand, induces a phosphorylation of the pro-survival factor STAT3. |
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