| Cat.No. | Name | Information |
|---|---|---|
| M3648 | HO-3867 | HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3970 | Scutellarin | Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. |
| M2883 | Nifuroxazide | Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| M2028 | Fludarabine (NSC 118218) | Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor. |
| M3032 | Stattic | Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
| M7747 | Diosgenin | Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. |
| M4433 | Alantolactone | Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone (helenin, helenine, Eupatal) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. |
| M9706 | Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M10077 | Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M49652 | CMD178 TFA | CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. |
| M49507 | W1131 TFA | W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. |
| M43967 | WB436B | WB436B is a potent, highly selective small molecule inhibitor of STAT3 that specifically targets the STAT3-SH2 structural domain with a KD value of 94.3 nM. |
| M42114 | STAT6-IN-3 | STAT6-IN-3 is a STAT6 inhibitor (IC50= 44 nM). |
| M42113 | STAT6-IN-2 | STAT6-IN-2 is an inhibitor of STAT6. |
| M42112 | STAT3 degrader-2 | STAT3 degrader-2 is a PROTAC-based degrader of STAT3. |
| M42111 | HJC0416 | HJC0416 is a potent and orally active STAT3 inhibitor. |
| M42110 | STAT3-IN-20 | STAT3-IN-20 is a selective STAT3 inhibitor (IC50: 0.65 μM). |
| M42109 | 8-Epixanthatin | 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. |
| M42108 | 7-epi-Isogarcinol | 7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. |
| M40553 | CLXR-005 | CLXR-005 is a STAT6 inhibitor that can be used in studies related to breast cancer. |
| M39011 | W1131 | W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway. |
| M39010 | Furowanin A | Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells. |
| M39009 | Eupalinolide K | Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) . |
| M39008 | (+)-Ochromycinone | (+)-Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+)-Ochromycinone is used in the researches of cancers and psoriasis. |
| M31371 | REX-4671 | REX-4671 is a STAT6 inhibitor that can be used in studies related to inflammation. |
| M31370 | REX-2787 | REX-2787 is a STAT6 inhibitor that can be used in studies related to inflammation. |
| M31278 | YM-341619 | YM-341619 (AS1617612) is a potent, orally active STAT6 inhibitor with an IC50 value of 0.70 nM. It can be used in studies related to allergic diseases (e.g., asthma and atopic rhinitis) by selectively inhibiting the differentiation of CD4(+) T cells into the Th2 subpopulation, and thereby inhibiting the ability to inhibit allergen-induced Th2 responses. |
| M31229 | Stafia-1-dipivaloyloxymethyl ester | Stafia-1-dipivaloyloxymethyl ester is a potent and selective STAT5a inhibitor. Stafia-1-dipivaloyloxymethyl ester (0-200 μM) decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b. |
| M30803 | SC99 | SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities. |
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