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Fludarabine

Cat. No. M2028
Fludarabine Structure
Synonym:

Fludara

Size Price Availability Quantity
10mg USD 72 In stock
50mg USD 225 In stock
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Biological Activity

Fludarabine (Fludara) is a purine analog that inhibits DNA synthesis. Fludarabine is used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas). Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Furthermore, fludarabine reduced neointimal formation after balloon angioplasty in a dose-dependent manner, and fludarabine-eluting stents reduced neointimal hyperplasia by approximately 50%. Fludarabine induces apoptosis of cancer cells and RNA transcription inhibitor. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Fludarabine displays anticancer activity against hematological malignancies in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 285.23
Formula C10H12FN5O4
CAS Number 21679-14-1
Purity 100.00%
Solubility DMSO 55 mg/mL
Storage at -20°C
References

Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo.
Meng H, et al. Eur J Haematol. 2007 Dec;79(6):486-93. PMID: 17976186.

Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
Torella D, et al. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43. PMID: 17293493.

Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia.
Eichhorst BF, et al. Blood. 2006 Feb 1;107(3):885-91. PMID: 16219797.

Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia.
Tournilhac O, et al. Blood. 2004 Jan 1;103(1):363-5. PMID: 12969985.

In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia.
Bellosillo B, et al. Blood. 1999 Oct 15;94(8):2836-43. PMID: 10515887.

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Keywords: Fludarabine, Fludara supplier, STAT, inhibitors

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