|M9177||SirReal2||SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.|
|M9148||SRT2104||SRT2104 is a selective brain-permeable activator of SIRT1.|
|M8978||3-TYP||3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.|
|M8213||Salvianolic acid B||Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease.|
|M6254||OSS_128167||OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.|
|M6241||Tenovin 6 Hydrochloride||Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.|
|M5265||Thiomyristoyl||Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.|
|M4896||Nicotinamide||Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.|
|M4678||Fisetin||Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.|
|M3010||Sirtinol||Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively.|
|M2267||Resveratrol||Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects.|
|M1824||SRT1720 Hydrochloride||SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively).|
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