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Resveratrol

Cat. No. M2267
Resveratrol Structure
Size Price Availability Quantity
200mg USD 50 In stock
500mg USD 100 In stock
1g USD 200 In stock
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Quality Control
Biological Activity

Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Resveratrol slightly inhibited ethoxyresorufin O-deethylation (EROD) activity in human liver microsomes with an IC50 of 1.1 mM.

Protocol
Cell Experiment
Cell lines CNE-1 and CNE-2Z cells
Preparation method Cell proliferation assay
The effect of resveratrol on the cell growth of CNE-1 and CNE-2Z cells was examined using the MTT assay. Cancer cells were plated in 96-well plates at 104 cells/well. Following pretreatment with different concentrations of resveratrol for 24 or 48 h, viable cells were determined using the MTT Assay kit (Chemicon, Temecula, CA, USA) according to the manufacturer’s protocol. At indicated time-points, 20 μl of MTT solution (5 mg/ml in PBS) were added into each well and incubated for 4 h. Then, 100 μl of DMSO was added to dissolve the crystals. The plate was then left to stand for 10 min at room temperature and the corresponding absorbance was measured at 490 nm. Each experiment was performed in triplicate.
Concentrations 0, 10, 25, 50 and 100 μM
Incubation time 24 or 48 h
Animal Experiment
Animal models female nude mice bearing CNE-2Z tumour xenograft model
Formulation 10% DMSO in PBS
Dosages 20 mg/kg once a day for 3 weeks
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 228.24
Formula C14H12O3
CAS Number 501-36-0
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signaling pathways.
Zhang M, et al. Int J Mol Med. 2013 Mar;31(3):621-7. PMID: 23314035.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Resveratrol supplier, Sirtuin, inhibitors

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