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SirReal2

Cat. No. M9177
SirReal2 Structure
Size Price Availability Quantity
10mg USD 160  USD160 In stock
50mg USD 630  USD630 In stock
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Quality Control & Documentation
Biological Activity

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

Chemical Information
Molecular Weight 421
Formula C22H20N4OS2
CAS Number 709002-46-0
Solubility (25°C) DMSO 84 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shiv Bharadwaj, et al. Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations

[2] Z-A Qu, et al. SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis

[3] Dejun Xu, et al. SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes

[4] Nicole A Spiegelman, et al. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities

[5] Yang Li, et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism

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