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UBCS039

Cat. No. M9876
UBCS039 Structure
Synonym:

UBCS 039

Size Price Availability Quantity
5mg USD 165  USD165 In stock
10mg USD 255  USD255 In stock
25mg USD 525  USD525 In stock
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Quality Control & Documentation
Biological Activity

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy.

Chemical Information
Molecular Weight 247.29
Formula C16H13N3
CAS Number 358721-70-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sara Iachettini, et al. Cell Death Dis. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

[2] Weijie You, et al. Angew Chem Int Ed Engl. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

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Keywords: UBCS039, UBCS 039 supplier, Sirtuin, inhibitors, activators


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