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CAY10602

Cat. No. M10295
CAY10602 Structure
Synonym:

CAY-10602

Size Price Availability Quantity
5mg USD 45  USD45 In stock
10mg USD 65  USD65 In stock
25mg USD 110  USD110 In stock
50mg USD 190  USD190 In stock
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Quality Control & Documentation
Biological Activity

CAY10602 is a SIRT1 activator, which suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells dose-dependently. CAY10602 exerts strong suppression of TNF-α release at concentrations between 20 and 60 μM.

Chemical Information
Molecular Weight 418.44
Formula C22H15FN4O2S
CAS Number 374922-43-7
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sebastian Hoppner, et al. Rapid Commun Mass Spectrom. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes

[2] Vasantha M Nayagam, et al. J Biomol Screen. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents

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Keywords: CAY10602, CAY-10602 supplier, Sirtuin, inhibitors, activators


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