Mdl-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family responsible for deacetylation of histone H3K9Ac and H3K56ac, with tumor suppressive activity. Mdl-800 increased SIRT6 deacetylase activity by up to 22 times, leading to cell cycle arrest and inhibiting its proliferation. It also inhibited the growth of hepatocellular carcinoma line BEL7405 xenograft.
Molecular Weight | 626.3 |
Formula | C21H16BrCl2FN2O6S2 |
CAS Number | 2275619-53-7 |
Solubility (25°C) | N/A |
Storage | 2-8°C |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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