Free shipping on all orders over $ 500

Fisetin

Cat. No. M4678
Fisetin Structure
Synonym:

Fustel

Size Price Availability Quantity
10mM*1mL in DMSO USD 48  USD48 In stock
100mg USD 50  USD50 In stock
500mg USD 65  USD65 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

Product Citations
Chemical Information
Molecular Weight 286.24
Formula C15H10O6
CAS Number 528-48-3
Solubility (25°C) DMSO 57 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qian Ren, et al. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

[2] Dharambir Kashyap, et al. Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

[3] Shengnan Jia, et al. Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

[4] Matthew J Yousefzadeh, et al. Fisetin is a senotherapeutic that extends health and lifespan

[5] Harish C Pal, et al. Fisetin and Its Role in Chronic Diseases

Related Sirtuin Products
ADTL-SA1215

ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer.

SIRT2/6-IN-1

SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM.

SIRT6-IN-2

SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM).

SIRT6-IN-3

SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM).

Z26395438

Z26395438 is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Fisetin, Fustel supplier, Sirtuin, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.