Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
Mol Biol Rep. 2023 Jun 21.
Effect and mechanism of Fisetin on myocardial damage induced by Patulin
Fisetin purchased from AbMole
Molecular Weight | 286.24 |
Formula | C15H10O6 |
CAS Number | 528-48-3 |
Solubility (25°C) | DMSO 57 mg/mL |
Storage | 2-8°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Matthew J Yousefzadeh, et al. Fisetin is a senotherapeutic that extends health and lifespan
[5] Harish C Pal, et al. Fisetin and Its Role in Chronic Diseases
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