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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M4614 | Orientin | Orientin |
| M10981 | Thymol | Thymol is the main monoterpene phenol present in essential oils, which are isolated from plants belonging to the family Lipaceae and other plants such as Verbenaiaceae, Psylliaceae, Buttercupaceae, etc. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects. |
| M10573 | (+/-)-Lisofylline | (±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. |
| M10093 | α-Galactosyl Ceramide | α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) is a potent NKT cell stimulator and selective CD1d ligand. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. |
| M9509 | NS-3-008 hydrochloride | NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. |
| M9358 | ITE | ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. |
| M9298 | AX-024 hydrochloride | Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. |
| M9122 | Tormentic Acid | Tormentic Acid is a natural anti-inflammatory agent which inhibits production of tumor necrosis factor‑α (TNF‑α), interleukin 6 (IL‑6), and IL‑1β. |
| M9117 | W-54011 | W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist, which inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. |
| M8247 | AUDA | AUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. |
| M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD. |
| M6219 | Rituximab | Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD. |
| M4877 | Karminomitsin | Karminomitsin is a very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. |
| M4825 | SKQ1 | SKQ1 is a potent mitochondria-targeted antioxidant. |
| M4791 | Tussilagone | Tussilagone is a major active component in Tussilago farfara, has anti-inflammatory effect. |
| M4790 | β-demonic-acid | β-demonic-acid exhibits anti-inflammatory effects. |
| M4750 | Echinocystic-acid | Echinocystic-acid |
| M4724 | Leonurine hydrochloride | Leonurine hydrochloride |
| M4704 | Diosgenin-glucoside | Diosgenin-glucoside is a saponin compound extracted from Tritulus terrestris L., protects against spinal cord injury by regulating autophagy and alleviating apoptosis. |
| M4686 | Eriodictyol | Eriodictyol |
| M4614 | Orientin | Orientin |
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