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Orientin

Cat. No. M4614
Orientin Structure
Size Price Availability Quantity
10mg USD 160  USD200 In stock
20mg USD 272  USD340 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Orientin

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 448.38
Formula C21H20O11
CAS Number 28608-75-5
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

[1] Li Wang, et al. Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A

[2] Cong Qiu, et al. Orientin and vitexin production by a one-pot enzymatic cascade of a glycosyltransferase and sucrose synthase

[3] Zi-Li Kong, et al. Orientin Protects Podocytes from High Glucose Induced Apoptosis through Mitophagy

[4] Chunmeng Li, et al. Orientin suppresses oxidized low-density lipoproteins induced inflammation and oxidative stress of macrophages in atherosclerosis

[5] Kit Ying Lam, et al. A Review on Medicinal Properties of Orientin

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