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Naringenin

Cat. No. M4000
Naringenin Structure
Synonym:

(±)-Naringenin; Salipurol; CAS# 480-41-1

Size Price Availability Quantity
100mg USD 55  USD55 In stock
500mg USD 90  USD90 In stock
1g USD 132  USD132 In stock
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Quality Control & Documentation
Biological Activity

Naringenin blocks the assembly of intracellular infectious viral particles, upstream of viral egress. Naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production. Naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice.

In vitro Naringenin reduces oxidative damage to DNA. Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells. Naringenin reduces cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase). Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.

Another CAS# 480-41-1

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Mice
Formulation dispersed in 0.5% sodium carboxymethyl cellulose
Dosages 50 or 100 mg/kg/day
Administration orally gavage
Chemical Information
Molecular Weight 272.25
Formula C15H12O5
CAS Number 67604-48-2
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Amayrani Abrego-Peredo, et al. PLoS One. Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile

[2] Qinyu Wang, et al. Br J Pharmacol. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

[3] Yen HR, et al. Chem Biol Interact. Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.

[4] Goldwasser J, et al. J Hepatol. Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.

[5] Nahmias Y, et al. Hepatology. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin.

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Keywords: Naringenin, (±)-Naringenin; Salipurol; CAS# 480-41-1 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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