Naringenin

Biological Activity

Naringenin blocks the assembly of intracellular infectious viral particles, upstream of viral egress.Naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production.Naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice.in vitro Naringenin reduces oxidative damage to DNA. Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells.Naringenin reduces cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase).Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information

References

Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Yen HR, et al. Chem Biol Interact. 2015 Apr 9;235:1-9. PMID: 25866363.

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.
Goldwasser J, et al. J Hepatol. 2011 Nov;55(5):963-71. PMID: 21354229.

Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin.
Nahmias Y, et al. Hepatology. 2008 May;47(5):1437-45. PMID: 18393287.