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Naringenin blocks the assembly of intracellular infectious viral particles, upstream of viral egress.Naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production.Naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice.in vitro Naringenin reduces oxidative damage to DNA. Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells.Naringenin reduces cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase).Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet.
Another CAS# 67604-48-2
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 272.25 |
| Formula | C15H12O5 |
| CAS Number | 480-41-1 |
| Purity | >98% |
| Solubility | DMSO 50 mg/mL |
| Storage | at -20°C |
| Related Cytochrome P450 (e.g. CYP17) Products |
|---|
| Schisandrin A
Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively. |
| Pradefovir mesylate
Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM. |
| N-Nornuciferine
N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. |
| Friedelin
Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). |
| Curcumenol
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. |
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