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Naringenin

Cat. No. M4000
Naringenin Structure
Synonym:

NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol, CAS# 67604-48-2

Size Price Availability Quantity
100mg USD 55  USD55 In stock
500mg USD 90  USD90 In stock
1g USD 132  USD132 In stock
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Quality Control
Biological Activity

Naringenin blocks the assembly of intracellular infectious viral particles, upstream of viral egress.Naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production.Naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice.in vitro Naringenin reduces oxidative damage to DNA. Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells.Naringenin reduces cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase).Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet.

Another CAS# 67604-48-2

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 272.25
Formula C15H12O5
CAS Number 480-41-1
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Yen HR, et al. Chem Biol Interact. Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.

[2] Goldwasser J, et al. J Hepatol. Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.

[3] Nahmias Y, et al. Hepatology. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin.

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Keywords: Naringenin, NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol, CAS# 67604-48-2 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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