11beta,13-Dihydrolactucin is a sesquiterpene lactone obtained by formal hydrogenation across the 11,13-double bond of lactucin. Found in chicory It has a role as a plant metabolite. It is functionally related to a lactucin. It belongs to the class of guaianolides and has several potential applications in the field of scientific research. 11beta,13-Dihydrolactucin has several biological properties, including antioxidant, anti-inflammatory, and antitumor activities. It has also been shown to have a positive impact on the immune system and to act as an antimicrobial agent.
| Molecular Weight | 278.3 |
| Formula | C15H18O5 |
| CAS Number | 83117-63-9 |
| Solubility (25°C) | Soluble in ethanol, methanol, and chloroform |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Dinara Satmbekova, et al. Nat Prod Res. Chemical and biological studies on Cichorium intybus L
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