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(+/-)-Lisofylline

Cat. No. M10573
(+/-)-Lisofylline Structure
Synonym:

Penthydroxifillyne

Size Price Availability
1mg USD 90  USD90 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

(±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. Lisofylline was able to suppress IFN-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 280.32
Formula C13H20N4O3
CAS Number 6493-06-7
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

[1] Z-D Yang, et al. Diabetologia. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice

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Keywords: (+/-)-Lisofylline, Penthydroxifillyne supplier, Immunology/Inflammation, inhibitors

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