Talniflumate is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma.
Molecular Weight | 414.33 |
Formula | C21H13F3N2O4 |
CAS Number | 66898-62-2 |
Solubility (25°C) | DMSO 61 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Darryl Knight. Curr Opin Investig Drugs. Talniflumate (Genaera)
Related Immunology/Inflammation Products |
---|
Lobenzarit
Lobenzarit is an immunomodulator, possesses anti-oxidative. |
ORIC-533
ORIC-533 is a highly potent and selective, orally bioavailable, Best-in-Class small molecule inhibitor of CD73, an enzyme expressed by various cell types, including immune cells and which catalyzes the generation of adenosine from adenosine monophosphate (AMP). |
Naringenin
Naringenin is the predominant flavanone in Citrus reticulata Blanco, it displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity. |
BK50164
BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. |
CCT374705
CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.