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HMG-CoA Reductase HMG-CoA Reductase

Cat.No.  Name Information
M5430 Atorvastatin hemicalcium Atorvastatin hemicalcium (CI-981) is an orally active inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
M2956 Pravastatin sodium Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
M2283 Rosuvastatin calcium Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M2126 Fluvastatin sodium Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes.
M1575 Lovastatin Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent).
M40866 Meglutol Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase.
M31158 4-Hydroxy atorvastatin calcium salt 4-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM.
M31157 2-Hydroxy atorvastatin calcium salt 2-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM.
M28512 Rosuvastatin Sodium Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
M9116 Atorvastatin Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.
M3527 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
M45124 Fluvastatin Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway.
M42446 Pravastatin lactone Pravastatin lactone is a potent HMG-CoA inhibitor.
M42445 HMG-CoA Reductase-IN-1 HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor.
M42444 Ganomycin I Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase.
M42443 Ganoderenic acid K Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum.
M42442 Bemfivastatin Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin.
M30577 Lovastatin hydroxy acid sodium Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
M28490 Cerivastatin Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
M28423 Cerivastatin sodium Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.




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