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Atorvastatin Calcium

Cat. No. M5430

Atorvastatin Calcium Structure
Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 80 In stock
50mg USD 85 In stock
500mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1155.34
Formula 2(C33H34FN2O5).Ca
CAS Number 134523-03-8
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
Customer Product Validations & Biological Datas
Source Pak J Pharm Sci (2016). Figure 1. Atorvastatin calcium (Abmole Bioscience)
Method HPLC chromatogram
Cell Lines
Concentrations 200μg/ml
Incubation Time
Results The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.
Rating
Product Citations
References

Preparation and evaluation of solid dispersion of atorvastatin calcium with Soluplus® by spray drying technique.
Ha ES, et al. Chem Pharm Bull (Tokyo). 2014;62(6):545-51. PMID: 24881660.

Related HMG-CoA Reductase Products
Clinofibrate

Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.

Pravastatin sodium

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

Fluvastatin sodium

Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Atorvastatin Calcium supplier, HMG-CoA Reductase, inhibitors

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