Free shipping on all orders over $ 500

Lovastatin

Cat. No. M1575
Lovastatin Structure
Synonym:

MK-803

Size Price Availability Quantity
50mg USD 75 In stock
100mg USD 115 In stock
200mg USD 150 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 404.54
Formula C24H36O5
CAS Number 75330-75-5
Purity >98%
Solubility 8 mg/mL in DMSO
Storage at -20°C
Customer Product Validations & Biological Datas
Source Pak J Pharm Sci (2016). Figure 1. Lovastatin (Abmole Bioscience)
Method HPLC chromatogram
Cell Lines
Concentrations 200μg/ml
Incubation Time
Results The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.
Rating
Product Citations
Related Products
Telotristat ethyl

Telotristat ethyl, also known as LX1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor.

ML-18

ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM).

Acecainide HCl

Acecainide HCl, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide.

Sematilide hydrochloride

Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent.

EBE-A22

EBE-A22 is a derivative of PD 153035, has no effect on EGF-R TK but maintains a high cytotoxic profile.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lovastatin, MK-803 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.