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Pravastatin sodium

Cat. No. M2956
Pravastatin sodium Structure
Size Price Availability Quantity
200mg USD 140 In stock
1g USD 460 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 446.51
Formula C23H35O7.Na
CAS Number 81131-70-6
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Pak J Pharm Sci (2016). Figure 1. Pravastatin sodium (Abmole Bioscience)
Method HPLC chromatogram
Cell Lines
Concentrations 200μg/ml
Incubation Time
Results The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.
Rating
Product Citations
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pravastatin sodium supplier, HMG-CoA Reductase, inhibitors

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