Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
Molecular Weight | 481.53 |
Formula | C26H33FNNaO5 |
CAS Number | 143201-11-0 |
Form | Solid |
Solubility (25°C) | Water 100 mg/mL (ultrasonic and warming and heat to 60°C) |
Storage | -20°C, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Stephen P Adams, et al. Cochrane Database Syst Rev. Cerivastatin for lowering lipids
[2] A Cheng-Lai. Heart Dis. Cerivastatin
[3] W Mück. Clin Pharmacokinet. Clinical pharmacokinetics of cerivastatin
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Fluvastatin
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Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. |
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Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. |
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