Free shipping on all orders over $ 500

Ganomycin I

Cat. No. M42444
Ganomycin I Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase.

Chemical Information
Molecular Weight 342.43
Formula C21H26O4
CAS Number 1191255-15-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Phuong Thao Tran et al. Phytomedicine. Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1

[2] Kai Wang et al. J Med Chem. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo

[3] Baosong Chen et al. Fitoterapia. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α-glucosidase

[4] Kai Wang et al. Eur J Med Chem. A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice

[5] Riham Salah El Dine et al. J Nat Prod. Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum

Related HMG-CoA Reductase Products
Fluvastatin

Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway.
Pravastatin lactone

Pravastatin lactone is a potent HMG-CoA inhibitor.
HMG-CoA Reductase-IN-1

HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor.
Ganoderenic acid K

Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum.
Bemfivastatin

Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin.
  Catalog
Abmole Inhibitor Catalog




Keywords: Ganomycin I supplier, HMG-CoA Reductase, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.