Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase.
| Molecular Weight | 162.14 |
| Formula | C6H10O5 |
| CAS Number | 503-49-1 |
| Form | Solid |
| Solubility (25°C) | DMSO > 250 mg/mL |
| Storage | -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Dylan E Jones et al. Clin Chim Acta. 3-Methylglutaric acid in energy metabolism
[3] I Yoshida. Ryoikibetsu Shokogun Shirizu. [3-Hydroxy-3-methylglutaryl-CoA-lyase deficiency]
[4] T Lerman-Sagie. Pediatr Neurol. Behr syndrome
[5] C L Greene et al. J Neurogenet. 3-Hydroxy-3-methylglutaric aciduria
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin
Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway. |
| Pravastatin lactone
Pravastatin lactone is a potent HMG-CoA inhibitor. |
| HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. |
| Ganomycin I
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. |
| Ganoderenic acid K
Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. |
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