Catalog

HIF Hypoxia-inducible factors

Inhibitors

Cat.No.	Name	Information
M10501	PT2399	PT2399 is a potent and orally available antagonist of HIF-2 with an IC50 of 6 nM, PT2399 selectively disrupts the heterodimerization of HIF-2α with HIF-1β.
M10436	Belzutifan (PT2977)	Belzutifan (PT2977) is a second-generation orally active and selective HIF-2α inhibitor with an IC50 of 9 nM.
M10169	Vadadustat	Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor.
M9842	ML228	ML228 is a potent the HIF pathway activator, with EC50 values of 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively.
M9675	Desidustat	Desidustat is an inhibitor of HIF hydroxylase.
M9279	LW6	LW6 is a novel HIF-1alpha inhibitor, with an IC50 of 4.4 μM.
M9198	JTZ-951	Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM.
M9066	PT2385	PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM.
M8963	JNJ-42041935	JNJ-42041935 is a potent, competitive, reversible, and selective inhibitor of PHD with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively.
M8924	Daprodustat	Daprodustat (GSK1278863) is a novel, orally active HIF-prolyl hydroxylase inhibitor.
M8678	FG-2216 (BIQ)	BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD) with IC50 of 3.9 uM for PDH2 enzyme.
M7929	PX 12	PX-12 inhibits the thioredoxin redox system and HIF-1a activity.
M5834	Oltipraz	Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.
M5795	Molidustat (BAY 85-3934)	Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.
M5276	MK-8617	MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
M5146	PX-478 2HCl	PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor.
M4869	BAY 87-2243	BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
M3991	YC-1	YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase.
M3977	Chlorogenic acid	Chlorogenic Acid is an analog of caffeic acid that displays antioxidant, analgesic, antipyretic and chemopreventive activity.
M2573	IOX2	IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
M2558	DMOG	DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
M1992	2-Methoxyestradiol	2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol acts via an estrogen receptor-independent mechanism.
M1726	FG-4592 (Roxadustat)	FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor.

Signaling Pathways

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HIF Hypoxia-inducible factors

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