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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9675 | Desidustat | Desidustat is an inhibitor of HIF hydroxylase. |
| M9279 | LW6 | LW6 is a novel HIF-1alpha inhibitor, with an IC50 of 4.4 μM. |
| M9198 | JTZ-951 | Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. |
| M9066 | PT2385 | PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM. |
| M8963 | JNJ-42041935 | JNJ-42041935 is a potent, competitive, reversible, and selective inhibitor of PHD with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively. |
| M8924 | Daprodustat | Daprodustat (GSK1278863) is a novel, orally active HIF-prolyl hydroxylase inhibitor. |
| M8678 | FG-2216 (BIQ) | BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD) with IC50 of 3.9 uM for PDH2 enzyme. |
| M7929 | PX 12 | PX-12 inhibits the thioredoxin redox system and HIF-1a activity. |
| M5834 | Oltipraz | Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3. |
| M5795 | Molidustat (BAY 85-3934) | Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2. |
| M5276 | MK-8617 | MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively. |
| M5146 | PX-478 2HCl | PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. |
| M4869 | BAY 87-2243 | BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. |
| M3991 | YC-1 | YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. |
| M3977 | Chlorogenic acid | Chlorogenic Acid is an analog of caffeic acid that displays antioxidant, analgesic, antipyretic and chemopreventive activity. |
| M2573 | IOX2 | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| M2558 | DMOG | DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase. |
| M1992 | 2-Methoxyestradiol | 2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol acts via an estrogen receptor-independent mechanism. |
| M1726 | FG-4592 | FG-4592 (ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. |
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