Catalog

HIF Hypoxia-inducible factors

Inhibitors

Cat.No.	Name	Information
M8963	JNJ-42041935	JNJ-42041935 is a potent, competitive, reversible, and selective inhibitor of PHD with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively.
M8924	Daprodustat	Daprodustat (GSK1278863) is a novel, orally active HIF-prolyl hydroxylase inhibitor.
M5795	Molidustat (BAY 85-3934)	Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.
M5276	MK-8617	MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
M5146	PX-478 2HCl	PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor.
M4869	BAY 87-2243	BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
M3977	Chlorogenic acid	Chlorogenic Acid is an analog of caffeic acid that displays antioxidant, analgesic, antipyretic and chemopreventive activity.
M2573	IOX2	IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
M1992	2-Methoxyestradiol	2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol acts via an estrogen receptor-independent mechanism.
M1726	FG-4592	FG-4592 (ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor.