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DMOG

Cat. No. M2558
DMOG Structure
Synonym:

Dimethyloxalylglycine

Size Price Availability Quantity
50mg USD 70 In stock
100mg USD 110 In stock
500mg USD 450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.

Customer Product Validations & Biological Datas
Source Int J Biol Sci (2018). Figure 3. DMOG
Method Western blot
Cell Lines BMSCs
Concentrations 0.5mM
Incubation Time 48 h
Results The number of surviving BMSCs cultured in normoxic condition was 8.3×10^3. The number of surviving cells number was 3.9×10^4 in the DMOG-treated group.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 175.14
Formula C6H9NO5
CAS Number 89464-63-1
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DMOG, Dimethyloxalylglycine supplier, HIF, inhibitors

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