Free shipping on all orders over $ 500

PT2385

Cat. No. M9066
PT2385 Structure
Synonym:

PT-2385

Size Price Availability Quantity
2mg USD 105  USD105 In stock
5mg USD 180  USD180 In stock
10mg USD 320  USD320 In stock
50mg USD 940  USD940 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PT2385 inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31).

Product Citations
Chemical Information
Molecular Weight 383.34
Formula C17H12F3NO4S
CAS Number 1672665-49-4
Solubility (25°C) DMSO: ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xie C, et al. Nat Med. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Related HIF Products
3-Aminobenzoic acid

3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.

Steppogenin

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.

HIV-IN-7

Axl-IN-16 is a Axl inhibitor.

HIF-2α-IN-9

HIF-2α-IN-9 is an inhibitor ofHIF-2α.

PHD-IN-2

PHD-IN-2 is a PHD antagonist (IC50: < 5 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: PT2385, PT-2385 supplier, HIF, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.