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PT2385

Cat. No. M9066
PT2385 Structure
Synonym:

PT-2385

Size Price Availability
5mg USD 360 4-7 Days
10mg USD 550 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PT2385 inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 383.34
Formula C17H12F3NO4S
CAS Number 1672665-49-4
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
Xie C, et al. Nat Med. 2017 Nov;23(11):1298-1308. PMID: 29035368.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PT2385, PT-2385 supplier, HIF, inhibitors

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