Free shipping on all orders over $ 500

Vadadustat

Cat. No. M10169
Vadadustat Structure
Synonym:

AKB-6548; B-506; PG-1016548

Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 200  USD200 In stock
25mg USD 370  USD370 In stock
50mg USD 520  USD520 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. Vadadustat works by active site iron chelating mechanisms in terms of inhibiting isolated PHD2.

Chemical Information
Molecular Weight 306.7
Formula C14H11CIN2O4
CAS Number 1000025-07-9
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tzu-Lan Yeh, et al. Chem Sci. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

[2] Nupur Gupta, et al. Am J Kidney Dis. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD

[3] Pablo E Pergola, et al. Kidney Int. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease

Related HIF Products
3-Aminobenzoic acid

3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.

Steppogenin

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.

HIV-IN-7

Axl-IN-16 is a Axl inhibitor.

HIF-2α-IN-9

HIF-2α-IN-9 is an inhibitor ofHIF-2α.

PHD-IN-2

PHD-IN-2 is a PHD antagonist (IC50: < 5 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: Vadadustat, AKB-6548; B-506; PG-1016548 supplier, HIF, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.