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Oltipraz

Cat. No. M5834
Oltipraz Structure
Synonym:

RP 35972; NSC 347901

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 100 In stock
100mg USD 155 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 226.34
Formula C8H6N2S3
CAS Number 64224-21-1
Purity 99.09%
Solubility 36 mg/mL warmed in DMSO
Storage at -20°C
References

The Effects of Oltipraz on Tissue Regeneration in the Process of Wound Healing: A Stereological Study.
Noorafshan A, et al. Bull Emerg Trauma. 2014 Oct;2(4):161-5. PMID: 27162890.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Oltipraz, RP 35972; NSC 347901 supplier, HIF, inhibitors

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