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FLT3 Fms-like tyrosine kinase 3


Cat.No.  Name Information
M1641 AC220 AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor.
M20679 SKLB4771 (FLT3-IN-1) SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.
M20359 WAY-304191 WAY-304191 is a CXCR3 antagonist.
M20343 WAY-299359 WAY-299359 is a FLT3 inhibitor
M20307 WAY-663387 WAY-663387 is a FLT3 kinase inhibitor.
M20061 WAY-297342 WAY-297342 is a inhibitor of Influenza Virus Polymerase
M14902 UNC2025 hydrochloride UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively.
M14901 Tandutinib hydrochloride Tandutinib hydrochloride (MLN518 hydrochloride) is a potent and selective inhibitor of the FLT3 with an IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50s of 0.17 μM and 0.20 μM, respectively.
M14899 Gilteritinib hemifumarate Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M14898 Dovitinib lactate Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.
M14897 AMG 925 HCl AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
M10850 Luxeptinib Luxeptinib (CG-806) is an orally active, reversible, best-in-class, non-covalent, potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle blocking, apoptosis, or autophagy in acute myeloid leukemia.
M10334 FF-10101 FF-10101 is a novel irreversible FLT3 inhibitor.
M10328 MRX-2843 MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively.
M10181 STK321130 STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor with IC50 of <1 μM.
M7527 Gilteritinib Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M5311 AMG 925 AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
M5142 G-749 G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
M5026 UNC-2025 UNC2025 is a potent, ATP-competitive, orally active Mer/Flt3 inhibitor.IC50 The values are 0.74 nM and 0.8 nM, respectively. UNC2025 is 45 times more selective for MERTK than Axl (IC50=122 nM; Ki=13.3 nM)。 UNC2025 has good PK properties and can be used in the study of acute leukemia.
M4646 Crotonoside Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
M3800 CGP52421 CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).

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