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FLT3 Fms-like tyrosine kinase 3


Cat.No.  Name Information
M1641 AC220 AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor.
M10850 Luxeptinib Luxeptinib (CG-806) is an orally active, reversible, best-in-class, non-covalent, potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle blocking, apoptosis, or autophagy in acute myeloid leukemia.
M10334 FF-10101 FF-10101 is a novel irreversible FLT3 inhibitor.
M10328 MRX-2843 MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively.
M10181 STK321130 STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor with IC50 of <1 μM.
M7527 Gilteritinib Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M5311 AMG 925 AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
M5142 G-749 G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
M5026 UNC-2025 UNC2025 is a potent, ATP-competitive, orally active Mer/Flt3 inhibitor.IC50 The values are 0.74 nM and 0.8 nM, respectively. UNC2025 is 45 times more selective for MERTK than Axl (IC50=122 nM; Ki=13.3 nM)。 UNC2025 has good PK properties and can be used in the study of acute leukemia.
M4646 Crotonoside Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
M3800 CGP52421 CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).
M3053 TCS 359 TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.
M1828 Tandutinib Tandutinib (MLN518), previously known as CT53518, is an orally active multitargeted tyrosine kinase inhibitor of FLT3, PDGFR and c-Kit.
M1815 KW-2449 KW-2449 is a novel multitargeted kinase inhibitor of FLT3, ABL and Aurora kinase with IC50 values of 6.6 nM, 14 nM and 48 nM.
M1641 AC220 AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor.

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