Catalog

FLT3 Fms-like tyrosine kinase 3

Inhibitors

Cat.No.	Name	Information
M10334	FF-10101	FF-10101 is a novel irreversible FLT3 inhibitor.
M10328	MRX-2843	MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively.
M10181	STK321130	STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor with IC50 of <1 μM.
M7527	Gilteritinib	Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M5311	AMG 925	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
M5142	G-749	G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
M5026	UNC-2025	UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
M3800	CGP52421	CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).
M3053	TCS 359	TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.
M1828	Tandutinib	Tandutinib (MLN518), previously known as CT53518, is an orally active multitargeted tyrosine kinase inhibitor of FLT3, PDGFR and c-Kit.
M1815	KW-2449	KW-2449 is a novel multitargeted kinase inhibitor of FLT3, ABL and Aurora kinase with IC50 values of 6.6 nM, 14 nM and 48 nM.
M1641	AC220	AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor.