FLT3 Fms-like tyrosine kinase 3

Inhibitors

Cat.No.	Name	Information
M1641	AC220	AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor.
M20679	SKLB4771 (FLT3-IN-1)	SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.
M20359	WAY-304191	WAY-304191 is a CXCR3 antagonist.
M20343	WAY-299359	WAY-299359 is a FLT3 inhibitor
M20307	WAY-663387	WAY-663387 is a FLT3 kinase inhibitor.
M20061	WAY-297342	WAY-297342 is a inhibitor of Influenza Virus Polymerase
M14902	UNC2025 hydrochloride	UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC₅₀ values of 0.74 nM and 0.8 nM, respectively.
M14901	Tandutinib hydrochloride	Tandutinib hydrochloride (MLN518 hydrochloride) is a potent and selective inhibitor of the FLT3 with an IC₅₀ of 0.22 μM, and also inhibits c-Kit and PDGFR with IC₅₀s of 0.17 μM and 0.20 μM, respectively.
M14899	Gilteritinib hemifumarate	Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M14898	Dovitinib lactate	Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.
M14897	AMG 925 HCl	AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
M10850	Luxeptinib	Luxeptinib (CG-806) is an orally active, reversible, best-in-class, non-covalent, potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle blocking, apoptosis, or autophagy in acute myeloid leukemia.
M10334	FF-10101	FF-10101 is a novel irreversible FLT3 inhibitor.
M10328	MRX-2843	MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively.
M10181	STK321130	STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor with IC50 of <1 μM.
M7527	Gilteritinib	Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
M5311	AMG 925	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
M5142	G-749	G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
M5026	UNC-2025	UNC2025 is a potent, ATP-competitive, orally active Mer/Flt3 inhibitor.IC50 The values are 0.74 nM and 0.8 nM, respectively. UNC2025 is 45 times more selective for MERTK than Axl (IC50=122 nM; Ki=13.3 nM)。 UNC2025 has good PK properties and can be used in the study of acute leukemia.
M4646	Crotonoside	Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
M3800	CGP52421	CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).

Signaling Pathways

Product Type

FLT3 Fms-like tyrosine kinase 3

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