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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M1641 | AC220 | AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor. |
| M10850 | Luxeptinib | Luxeptinib (CG-806) is an orally active, reversible, best-in-class, non-covalent, potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle blocking, apoptosis, or autophagy in acute myeloid leukemia. |
| M10334 | FF-10101 | FF-10101 is a novel irreversible FLT3 inhibitor. |
| M10328 | MRX-2843 | MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively. |
| M10181 | STK321130 | STK321130, also known as FLT3-IN-2, is potent FLT3 inhibitor with IC50 of <1 μM. |
| M7527 | Gilteritinib | Gilteritinib is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. |
| M5311 | AMG 925 | AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. |
| M5142 | G-749 | G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases. |
| M5026 | UNC-2025 | UNC2025 is a potent, ATP-competitive, orally active Mer/Flt3 inhibitor.IC50 The values are 0.74 nM and 0.8 nM, respectively. UNC2025 is 45 times more selective for MERTK than Axl (IC50=122 nM; Ki=13.3 nM)。 UNC2025 has good PK properties and can be used in the study of acute leukemia. |
| M4646 | Crotonoside | Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML. |
| M3800 | CGP52421 | CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412). |
| M3053 | TCS 359 | TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM. |
| M1828 | Tandutinib | Tandutinib (MLN518), previously known as CT53518, is an orally active multitargeted tyrosine kinase inhibitor of FLT3, PDGFR and c-Kit. |
| M1815 | KW-2449 | KW-2449 is a novel multitargeted kinase inhibitor of FLT3, ABL and Aurora kinase with IC50 values of 6.6 nM, 14 nM and 48 nM. |
| M1641 | AC220 | AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor. |
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