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TCS 359

Cat. No. M3053
TCS 359 Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.

Protocol
Cell Experiment
Cell lines MV4-11
Preparation method Plating MV4-11 cells at 10,000 cells per well in 100 μL of in RPMI media containing penn/strep, 10% FBS, and 0.2 ng/mL GM-CSF. Compound dilutions or 0.1% DMSO (vehicle control) is added to cells which are allowed to grow for 72 h at standard cell growth conditions.An equal volume of CellTiterGlo reagent is added to each well and luminescence is quantified in order to measure total cell growth . Total cell growth is quantified as the difference in luminescent counts of cell number at Day 0 compared to total cell number at Day 3 (72 h of growth and/or compound treatment).Calculated all IC50 values in GraphPadPrism using non-linear regression analysis with a multiparameter (variable slope) equation.
Concentrations ~5 μM
Incubation time 72 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 360.43
Formula C18H20N2O4S
CAS Number 301305-73-7
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TCS 359 supplier, FLT3, inhibitors

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