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TCS 359

Cat. No. M3053
TCS 359 Structure
Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.

Protocol (for reference only)
Cell Experiment
Cell lines MV4-11
Preparation method Plating MV4-11 cells at 10,000 cells per well in 100 μL of in RPMI media containing penn/strep, 10% FBS, and 0.2 ng/mL GM-CSF. Compound dilutions or 0.1% DMSO (vehicle control) is added to cells which are allowed to grow for 72 h at standard cell growth conditions.An equal volume of CellTiterGlo reagent is added to each well and luminescence is quantified in order to measure total cell growth . Total cell growth is quantified as the difference in luminescent counts of cell number at Day 0 compared to total cell number at Day 3 (72 h of growth and/or compound treatment).Calculated all IC50 values in GraphPadPrism using non-linear regression analysis with a multiparameter (variable slope) equation.
Concentrations ~5 μM
Incubation time 72 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 360.43
Formula C18H20N2O4S
CAS Number 301305-73-7
Solubility (25°C) DMSO
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tracey C Stephen, et al. Automated essay scoring (AES) of constructed responses in nursing examinations: An evaluation

[2] Hideya Seo, et al. A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production

[3] M C Rusu, et al. Skin telocytes

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  Catalog
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