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AMG 925

Cat. No. M5311
AMG 925 Structure
Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 200 In stock
50mg USD 580 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 471.55
Formula C26H29N7O2
CAS Number 1401033-86-0
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia.
Li C, et al. Mol Cancer Ther. 2015 Feb;14(2):375-83. PMID: 25487917.

Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Keegan K, et al. Mol Cancer Ther. 2014 Apr;13(4):880-9. PMID: 24526162.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AMG 925 supplier, FLT3, inhibitors

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