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G-749

Cat. No. M5142
G-749 Structure
Size Price Availability Quantity
2mg USD 160 In stock
5mg USD 240 In stock
10mg USD 360 In stock
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Quality Control
Biological Activity

In MV4-11 xenograft mice, G-749 (30 mg/kg p.o.) effectively inhibits the FLT3 pathway and significant inhibits tumor growth. In an orthogonal model of bone marrow engraftment using Molm-14 cells, G-749 (20 mg/kg p.o.) also inhibits tumor growth and increases survival.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 521.41
Formula C25H25BrN6O2
CAS Number 1457983-28-6
Purity
Solubility
Storage at -20°C
References

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia.
Lee HK,et.al. Blood 2014 Apr 3;2209-19. PMID: 24532805.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: G-749 supplier, FLT3, inhibitors

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