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CGP52421

Cat. No. M3800
CGP52421 Structure
Size Price Availability
5mg USD 90 Out of stock
10mg USD 150 Out of stock
50mg USD 450 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 600.66
Formula C36H32N4O5
CAS Number 179237-49-1
Purity >99%
Solubility DMSO
Storage at -20°C
References

Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus.
Wang Y, et al. J Clin Pharmacol. 2008 Jun;48(6):763-75. PMID: 18508951.

A highly sensitive method for the detection of PKC412 (CGP41251) and its metabolites by high-performance liquid chromatography.
Illmer T, et al. J Pharmacol Toxicol Methods. 2007 Jul-Aug;56(1):23-7. PMID: 17395497.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CGP52421 supplier, FLT3, inhibitors

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