|M7546||SMER 28||SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.|
|M7542||SBC-115076||SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Target: PCSK9 in vivo: SBC-115076 lowers cholesterol levels in mice that are fed high fat diet.|
|M6293||Tacrolimus monohydrate||Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer.|
|M6260||ROC-325||ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.|
|M6194||Esomeprazole Magnesium trihydrate||Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.|
|M6097||Corynoxine||Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.|
|M6086||SBI-0206965||SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .|
|M5649||Flubendazole||Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.|
|M5438||Azithromycin||Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.|
|M5196||Spautin-1||Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.|
|M5159||Hydroxychloroquine Sulfate||Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9.|
|M4844||Isobavachalcone||Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.|
|M2129||Temozolomide||Temozolomide is an oral DNA methylating, chemotherapeutic agent.|
|M1834||Omeprazol||Omeprazol is a proton pump inhibitor used in the treatment of dyspepsia, laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome.|
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