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Autophagy Autophagy


Cat.No.  Name Information
M1934 Tacrolimus (FK506) Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended
M2283 Rosuvastatin calcium Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M3380 Pitavastatin Calcium Pitavastatin Calcium is a new type of statin.
M3497 Simvastatin Simvastatin (Zocor) is a competitive inhibitor of HMG-COA reductase with K I of 0.1-0.2 nM. Simvastatin inhibits exosome release.
M2510 Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M11327 ABTL-0812 Abtl-0812 (α -hydroxylinoleic acid) induces ER stress-mediated autophagy and has anticancer activity.
M11298 Oleanolic Acid Oleanolic Acid (Oleanic Acid) is a natural compound with anticancer activity, widely distributed in edible and medicinal plants. It is related to betulinic Acid and has relatively non-toxic, anti-tumor, hepatoprotective and antiviral properties.
M11124 Corynoxine B Corynoxine B is a natural compound of indole alkaloid, a beclin-1-dependent autophagy inducer.
M11037 Cearoin Cearoin enhances autophagy and induces apoptosis by promoting ROS production and activating ERK.
M10988 Bergenin Bergenin is a cell protection and antioxidant polyphenol found in many medicinal plants. Bergenin has a wide range of hepatoprotective, anti-inflammatory, immunomodulatory, anti-tumor, antiviral, and antifungal effects.
M10731 ICCB-19 hydrochloride ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds to the N-terminal domain of TRADD (TRADD-N), breaking its binding to TRADD-C and TRAF2. ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and degradation of long-lived proteins.
M10546 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
M10277 EN6 EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
M10257 Glycycoumarin Glycycoumarin is a bioactive coumarin of licorice, it inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway.
M10165 TPEN TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
M10087 Ginkgolide K Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
M9851 GW406108X GW406108X is a potent autophagy inhibitor, with a pIC50 6.37 (427 nM) against ULK1.
M9702 QX77 QX77 is a novel chaperone-mediated autophagy (cma) activator.
M9610 LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound, interacts with both mutant huntingtin protein (mHTT) and LC3B.
M9559 Chloroquine Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.
M9457 Lanatoside C Lanatoside C is a cardiac glycoside, with IC50 of 0.19 μM for dengue virus infection in HuH-7 cells.
M9451 Curcumin analog C1 Curcumin analog C1 is a potent, orally effective transcription factor EB (TFEB) activator and is a potential therapeutic agent for the treatment of neurodegenerative diseases.
M9155 Autophinib Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin with IC50 values of 90 and 40 nM, targeting the lipid kinase VPS34 with IC50 value of 19 nM in vitro.
M9092 Hemin chloride Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis.
M9069 AS1842856 AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.

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