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Autophagy Autophagy

Cat.No.  Name Information
M9765 Dimethyl itaconate Dimethyl itaconate may be used in functionalization of isotactic poly(propylene).
M9559 Chloroquine Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.
M9451 Curcumin analog C1 Curcumin analogue C1 is an effective oral activator of transcription factor EB (TFEB), which can be used in the study of neurodegenerative diseases.
M9069 AS1842856 AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.
M9059 TBHQ TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator.
M6255 JPH203 JPH203, a selective L-type amino acid transporter 1 (LAT1) inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
M5961 Silibinin Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
M4124 6-Shogaol Shogaol ([6]-Shogaol) is an active substance isolated from ginger and has a variety of biological activities, including anti-cancer, anti-inflammatory and antioxidant activities.
M3497 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
M3380 Pitavastatin Calcium Pitavastatin Calcium is a new type of statin.
M2510 Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M2049 Metformin hydrochloride Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro.
M1934 Tacrolimus (FK506) Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended
M38859 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.
M22238 Emetine dihydrochloride hydrate Emetine dihydrochloride hydrate
M20648 DC661 DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).
M20551 CA-5f CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
M19865 Sulfacetamide sodium salt hydrate Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
M18477 Notoginsenoside Fc Notoginsenoside Fc is a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy.
M15099 Tat-beclin 1 Tat-beclin 1, a Beclin 1-derived peptide, is an effective inducer of autophagy and can stimulate autophagy by mobilizing endogenous Beclin 1. Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr




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