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  Catalog
Abmole Inhibitor Catalog 2017

Autophagy Autophagy

Inhibitors

Cat.No.  Name Information
M9092 Hemin chloride Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis.
M9069 AS1842856 AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.
M9059 TBHQ TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH.
M7546 SMER 28 SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
M7542 SBC-115076 SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Target: PCSK9 in vivo: SBC-115076 lowers cholesterol levels in mice that are fed high fat diet.
M6293 Tacrolimus monohydrate Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer.
M6260 ROC-325 ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.
M6255 JPH203 JPH203, a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
M6194 Esomeprazole Magnesium trihydrate Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
M6097 Corynoxine Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
M6086 SBI-0206965 SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .
M5649 Flubendazole Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
M5438 Azithromycin Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
M5196 Spautin-1 Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.
M5159 Hydroxychloroquine Sulfate Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
M5143 SR9009 SR9009 is an agonist of REV-ERB, with IC50 of 670 nM and 800 nM for REV-ERBα and REV-ERBβ respectively.
M4893 2-Hydroxypropyl-β-cyclodextrin 2-Hydroxypropyl-β-cyclodextrin is the most widely used modified cyclodextrin.
M4844 Isobavachalcone Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
M4522 Ursolic-acid Ursolic-acid
M3921 Dioscin Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.
M3699 Letrozole Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
M3690 Mefloquine hydrochloride Mefloquine hydrochloride is a quinoline antimalarial inhibitor that is structurally related to the antiarrhythmic agent quinidine.
M3510 Mifepristone Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.
M3499 Ezetimibe Ezetimibe (Zetia) is a compound that lowers cholesterol.
M3497 Simvastatin Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .
M3466 Indomethacin Indomethacin is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
M3424 Nifedipine Nifedipine (Adalat) is a potent vasodilator agent with calcium antagonistic action.
M3422 Capsaicin Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum.
M3380 Pitavastatin Calcium Pitavastatin calcium is a novel member of the medication class of statins.
M3327 Genipin Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.
M3292 Adenosine Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
M3291 Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
M3120 Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
M3107 UNC1999 UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.
M3104 UNC0638 UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets.
M3055 Tempol TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
M2996 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
M2659 E-64 E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
M2647 DMH1 DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
M2594 Montelukast sodium Montelukast sodium selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1.
M2510 Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M2472 Bromocriptine Mesylate Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.
M2450 Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
M2283 Rosuvastatin calcium Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M2280 Tamoxifen Citrate Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.
M2256 Ivermectin Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor.
M2227 Imiquimod Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.
M2226 Melatonin Melatonin is a hormone found naturally in the body.
M2198 Curcumin Curcumin is an antitumor, anti-inflammatory and antioxidant agent.
M2176 Dexamethasone Dexamethasone is a potent anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein.


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